On the other hand, the problem of gene effect and gene action in a vertebrate organism stands alone in many respects, both from the theoretical and the practical point of view. It also is true that Drosophila has been analyzed so thoroughly genetically that it might offer better material for the study of the physiological mecha. provide a material more accessible to the analysis of biochemical gene effects. But there are a number of reasons why just the house mouse (Mus musculus L.) lends itself well to a discussion of problems of physiological genetics. INTRODUCTION A review article on the physiological genetics of the mouse might at first sight appear to have chosen too limited a n object for discussion. F u s e d 7 Abnormalities of t ' / P Embryos 8 Miscellaneous Abnormalities in Individuals Carrying Mutations of Chromosome I X 9 The Role of Chromosome I X in Embryonic Growth and Differentiation Developmental Changes Induced by X-Rays Concluding Remarks References Screw Tail d Undulated e Danforth's Short Tail The Developmental Effects of Mutations in Chromosome I X of the Mouse 1 Brachy6ry-Heterozygous Effect of T 2 Taillessness T/tn 3 Homozygous Effect of T 4 t-Type Mutations-Developmental Effects of t", t', t' 5 Kink-Homozygous Effect of Ei 6. 29 30 30 30 30 31 31 31 32 32 32 33 33 34 35 35 36 36 37 37ī Tooth Abnormalities i Grey-Lethal ii Screw Tail 2 Extremities a L u x M o n g e n i t a l Absence of Tibia b Luxate c Polydactyly i Development ii Polydactyly and Embryonic Blebs iii Polydactyly and Central Nervous System iv Polydactyly and Maternal Age d Grey-Lethal and Failure of Secondary Bone Absorption 3.Sternum a Screw Tail b Short Ear 4 Spinal Column a.Flexed b Shaker Short c.
#Primordia puge skin#
a Classic Case of a Lethal Mutation I11 Analysis of Gene-Determined Pigment Characters 1 Autonomy of Pigmentation a Mutant Spots b Transplantation 2 Histological Studies of Pigmentation in Different Gene Substitutions 3 Biochemical Studies of Pigmentation in Different Genotypes 4 Correlation of Histological and Biochemical Results 5 Tyrosinase System in the Determination of Pigment Pattern I V Analysis of Gene-Determined Abnormalities of the Blood 1 Siderocytic Anemia in Flexed 2 Macrocytic Anemia in Dominant Spotting V Analysis of Mutat.ions Affecting the Skin and Its Derivatives 1 Transplantation Studies in Waved-2 2 Transplantation Studies in Rhino 3 Rhino and Vitamin A 4 Developmental Studies of Crinkled V I Developmental Studies of Mutations Affecting the Urogenital Sy.stem 1 Kidney Development in Myelencephalic Blebs 2 Kidney Development in Danforth’s Short Tail 3 Inductive Relationship between Ureter and Metanephros 4 Urogenital Syndrome V I I Developmental Studies of Mutations Affecting the Central Nervous System and Sensory Organs 1 Hydrocephalus 2 Congenital Hydrocephalus 3 Pseudencephaly 4 X-Ray-Induced Translocations and Pseudencephaly 5 Shaker Short a Central Nervous System b Ear 6 Effect of Kreisler 011 the Central Nervous System and Ear 7 Eyelees 8 Microphthalmus VIII Analysis of Endocrine Disturbances-Pituitary Dwarfism I X Analyeis of Mutations Affecting the Skeleton 1 Skull a.Harelip 1Ĩ 8 9 10 11 11 11 12 14 14 15 15 16 17 17 17 18 18 19 19 20 21 22 23 23 24 24 26
I Introduction I1 Analysis of the Yellow Lethal. Physiological Genetics of the Mouse SALOME GLUECKSOHN-WAELSCH Department of Zoology. WHITE,The University of Texas, Austin, Texas STEPHENS, Department of A g r o w m y, North Carolina State College, Raleigh, North Carolina RICHMOND, Texas AgriculturaJ Experiment Xtatim, Texas Agricultural and Mechanical College System, College Station, Texas, and U. MATTHEY, Laboratoire de Zoologie, Universite' de Lausanne, Lausanne, Switzerland SEIJINNAGAO, Plant Breeding Institute, Hokkaido University, Sapporo, Japan T. RRUG,Instituto Agrolzdmico, Campinas, SGo Paulo, Brazil amtomisches Ircstitut, University of Zurich, LYwitzerlandĪLOHAHANNAH,Department of Zoology, University of California, Berkeley, CaliforniaĬ. CARVALHO, Instituto Agrm6mico, Campinas, SGo Paulo, Brazil SALOME GLUECKSOHN-WAELSCH, Department of Zoology, Columbia University, New Y m k, New York ERNSTIIADORN,Zoologisch-vergl. PRINTED IN T H E UNITED STATES O F AMERICAĪ.
1įirst Printing, 1951 Second Printing, 1964 ĪLL RIGHTS RESERVED NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM BY PHOTOSTAT, MICROFILM, OR ANY OTHER MEANS, WITHOUT WRITTEN PERMISSION FROM T H E PUBLISHERSĪCADEMIC PRESS INC. STADLER CURT STERNĪCADEMIC PRESS INC., PUBLISHERS N E W YORK, N. DEMEREC Carnegie Institution, Cold Spring Harbor, N.